Define autologous stem cell transplant7/14/2023 ![]() ![]() Currently, only a few comparative studies, most of them retrospective, between different conditioning protocols regarding efficacy and toxicity have been published. Recently, concerns regarding BCNU toxicity as well as restricted availability of BCNU and melphalan has determined an increasing number of transplant centers to use alternative conditioning regimens. BEAM (BCNU/carmustine, etoposide, cytarabine, and melphalan) is the most commonly used conditioning regimen for ASCT in patients with relapsed/refractory (R/R) lymphomas in Europe, whereas the CBV (cyclophosphamide, BCNU, and etoposide) regimen is also widely used in North America. ![]() ASCT is considered the standard treatment for eligible patients failing to achieve remission after first line chemotherapy or patients with relapsed or refractory lymphomas, including classical Hodkin's lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, as well as consolidation therapy in first remission in mantle cell lymphoma. In Europe over 8,000 ASCTs for lymphoma were performed out of a total of 40,000 transplants according to the European Bone Marrow Transplant (EBMT) activity survey in 2017. High-dose chemotherapy (HDT) followed by autologous hematopoietic stem cell transplantation (ASCT) is widely used in patients with malignant lymphomas. 9Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania. ![]() 8Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.7Department of Hematology, Ion Chiricuta Clinical Cancer Center, Cluj Napoca, Romania.6Department of Hematology, Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.5Department of Stem Cell Transplantation, University Hospital, Bucharest, Romania.4Department of Stem Cell Transplantation, Fundeni Clinical Institute, Bucharest, Romania.3Department of Pediatrics, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.2Department of Stem Cell Transplantation, Coltea Clinical Hospital, Bucharest, Romania.1Department of Hematology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.Andrei Colita 1,2 †, Anca Colita 3,4 †, Horia Bumbea 1,5 †, Adina Croitoru 4 †, Carmen Orban 4 †, Lavinia Eugenia Lipan 4, Oana-Gabriela Craciun 4, Dan Soare 1,5, Cecilia Ghimici 1,2, Raluca Manolache 1,2, Ionel Gelatu 1,2, Ana-Maria Vladareanu 1, Sergiu Pasca 6,7, Patric Teodorescu 7,8, Delia Dima 7, Anca Lupu 1,2, Daniel Coriu 1,9, Ciprian Tomuleasa 6,7 * and Alina Tanase 4 ![]()
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